The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. Folliculin (FLCN) is also associated with Birt–Hogg–Dubé syndrome, which is an … Skatīt vairāk Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 … Skatīt vairāk Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin … Skatīt vairāk • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports … Skatīt vairāk • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. … Skatīt vairāk Tīmeklis2024. gada 21. nov. · FLCN-FNIP1 is recruited to damaged mitochondria, and this process is inhibited in cells expressing RAB7AS72A. Moreover, nonphosphorylatable …
Mutation of Fnip1 is associated with B-cell deficiency ... - PNAS
Tīmeklis2024. gada 10. apr. · Autophagy also plays a key role in tumor resistance to chemotherapy, radiotherapy or targeted therapy. Inhibition of autophagy is therefore … TīmeklisLC3 and GABARAP members of the ATG8 protein family are required for selective autophagy and sensing perturbation within the endolysosomal system. Here, we … flight by wire installer
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TīmeklisPirms 4 stundām · Autophagy is known to be closely involved with infection by SARS-CoV-2 and its elimination, thus making autophagy-related compounds potential … Tīmeklis2024. gada 24. marts · Autophagy was initially described as an adaptive process to starvation, promoting energy maintenance; the recycling of senescent or disabled macromolecules and organelles; and providing the building blocks for de novo synthesis of macromolecules. Autophagy is highly conserved among eukaryotes. Tīmeklis2014. gada 22. jūl. · FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. ... chemical structure of flour