In organic chemistry, hydroamination is the addition of an N−H bond of an amine across a carbon-carbon multiple bond of an alkene, alkyne, diene, or allene. In the ideal case, hydroamination is atom economical and green. Amines are common in fine-chemical, pharmaceutical, and agricultural industries. … Meer weergeven Hydroamination is well-established technology for generating fragrances from myrcene. In this conversion, diethylamine adds across the diene substituent, the reaction being catalyzed by lithium diethylamide. … Meer weergeven Hydroamination reactions are atom-efficient processes that generally use readily available and cheap starting materials, therefore a general catalytic strategy is highly desirable. Also, direct catalytic hydroamination strategies have in principle … Meer weergeven The hydroamination reaction is approximately thermochemically neutral. The reaction however suffers from a high activation barrier, perhaps owing to the repulsion of the electron-rich substrate and the amine nucleophile. The intermolecular reaction … Meer weergeven Certain titanium and zirconium complexes catalyze intermolecular hydroamination of alkynes and allenes. Both stoichiometric and catalytic … Meer weergeven Hydroamination has been examined with a variety of amines, unsaturated substrates, and vastly different catalysts. Amines that have been investigated span a wide scope including primary, secondary, cyclic, acyclic, and anilines with diverse steric and electronic substituents. … Meer weergeven Strong bases catalyze hydroamination, an example being the ethylation of piperidine using ethene: Such base catalyzed reactions proceed well with ethene but higher alkenes are less reactive. Meer weergeven The addition of hydrogen and an amino group (NR2) using reagents other than the amine HNR2 is known as a "formal hydroamination" reaction. Although the advantages of atom economy and/or ready available of the nitrogen source are diminished … Meer weergeven WebWe report here a reaction that selectively deaminates primary amines and anilines under mild conditions and with remarkable functional group tolerance including a range of …
A Convenient Reductive Deamination (Hydrodeamination) of Aromatic ...
Web1 jul. 1992 · A Convenient Reductive Deamination (Hydrodeamination) of Aromatic Amines. The Journal of Organic Chemistry 2001, 66 (25) , 8293-8296. … rob ross hair
Link to VoR: http://dx.doi.org/10.1002/adsc.202400427 Adv. Synth …
WebHydrodeamination of N,N-dimethylaminoarenetricarbonylachromium complexes via cine and tele-meta nucleophilic aromatic substitutions Web14 mrt. 2024 · Again, these conditions are similar to previously reported photoredox‐catalyzed protocols by Gryko and co‐workers but proceed efficiently in the absence of a photocatalyst.14b Finally, we found that by replacing the unsaturated sulfones with other sulfur‐based reagents, under otherwise identical conditions, high yielding … Web17 aug. 2024 · A significant acceleration in the hydrodeamination of in situ formed diazonium salts (from aromatic amines) has been observed in the presence of 10-mol% … rob rothenberg