Incidence of thrombocytopenia with daptomycin
WebJun 27, 2024 · Drugs can cause thrombocytopenia by several mechanisms including direct bone marrow or other organ toxicity. Many of the cytotoxic drugs used for cancer chemotherapy and other conditions produce dose-dependent reductions in platelet counts … WebSep 7, 2024 · Daptomycin (DAP), a cyclic lipopeptide, ... Given the current low incidence of DAP-R among S. epidermidis in the United States, DAP susceptibility is not universally reported by clinical microbiology laboratories and may often only be inferred. However, increasing reports of DAP-NS CoNS isolates raise the importance of vigilant monitoring …
Incidence of thrombocytopenia with daptomycin
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WebApr 12, 2024 · Immune thrombocytopenia (ITP) is the consequence of a complex, still not completely understood immunological dysregulation. Proposed mechanisms include autoantibody-induced platelet destruction, impaired platelet production as well as abnormalities in T-cell immunity, such as Th1 polarization, a high proportion of Th17 cells … WebThe reported incidence of drug-induced thrombocytopenia (DIT) is 10 cases per 1 million people per year, but the number is presumed to be higher because of underreporting and …
WebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received daptomycin; however, there have been no previously reported cases of rhabdomyolysis in … WebApr 13, 2024 · Daptomycin has good skin and soft tissue penetration (reaching concentrations of approximately 70–90% of the free drug in the plasma) and concentrates in the urinary system (54% of the drug is excreted in its active form) . Unlike linezolid, daptomycin has poor CSF penetration and therefore is not an ideal antibiotic for …
WebNov 23, 2024 · Common side effects of daptomycin may include: chest pain, trouble breathing; headache, dizziness; stomach pain, vomiting; swelling; abnormal liver function tests; rash, itching, sweating; trouble sleeping; sore throat; or increased blood pressure. This is not a complete list of side effects and others may occur. WebSep 27, 2024 · Vancomycin causes several different types of hypersensitivity reactions, ranging from localized skin reactions to generalized cardiovascular collapse. The most common adverse reaction, vancomycin infusion reaction (VIR). VIR is a rate-dependent infusion reaction, not a true allergic reaction. Vancomycin hypersensitivity will be …
WebFirst, the time from daptomycin initiation to the diagnosis of thrombocytopenia was 4 days. Drug-dependent antiplatelet antibodies usually develop only after 1 to 2 weeks of drug exposure ( 1 ). However, the rapid drop in the patient's platelet count strongly suggests immune-mediated thrombocytopenia.
Webthe patient was initiated on daptomycin 6 mg/kg (300 mg) daily in response to wound cultures detecting Enterococcus faecium susceptible only to daptomycin and linezolid. Starting 96 hours after daptomycin initiation, there was a profound reduction in the patient’s WBC, reaching a nadir of 1.63 x 10-3 /µL after 12 days of therapy. Prior to ... dhfl latest newsWebNov 30, 2024 · Thrombocytopenia can occur in 10% to 30% of patients treated with heparin in the absence of an obvious involvement of the immune system. The underlying pathophysiology is thought to be mediated by direct binding of heparin to platelets, resulting in mild platelet activation. dhfl latest news for fd holdersWebJul 5, 2024 · Drug-induced non-immune thrombocytopenia. Drugs like valproic acid, daptomycin, linezolid cause thrombocytopenia by dose-dependent suppression of platelet production. Infections: Viral: HIV, hepatitis C, Ebstein-Barr virus, parvovirus, mumps, varicella, rubella, Zika viral infections can cause thrombocytopenia. cigar shop breckenridge coWebThe incidence of drug-induced thrombocytopenia is not well defined, in part because reporting is voluntary and is not critically reviewed. On the basis of several epidemiologic studies in the ... dhfl merger with iciciWebOct 1, 2012 · Although the incidence is low, more than 100 drugs have been implicated in thrombocytopenia, including quinine, sulfonamides, abciximab, carbamazepine, and vancomycin, as well as herbal remedies ... dhfl loan against propertyWebApr 2, 2024 · There was no difference in adverse event incidence between LZD and comparators. These findings suggest that LZD could be a potential first-line drug against MRSA bacteremia as well as VCM or DAP. Keywords: meta-analysis; linezolid; effectiveness; methicillin-resistant Staphylococcus aureus; bacteremia 1. Introduction cigar shop bourbon streetcigar shop beaverton