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Lxrα-cyp7a1

WebThis prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin.Of 64 consecutive dyslipidemic patients, 40 patients, whose level of total cholesterol or LDL … Web目的: 通过研究，明确lxrα和pparα在降脂中药黄连调控cyp7a1的作用，并阐明黄连调节cyp7a1的物质基础。 方法: 体内研究：健康雄性SD大鼠，体重在180-200g之间，用高脂饲料喂食建立高脂模型，鼠尾取血检测血清生化指标：总胆固醇(TC)、甘油三酯(TG)、高密度脂 …

Drug-Metabolizing Enzyme and Transporter Gene Polymorphisms …

Web10 ian. 2024 · The major bioactive flavonoid isorhamnetin (ISOR) also increased the protein expression of PPAR-γ, LXRα and CYP7A1. Conclusion: SF might promote cholesterol … WebWe characterize the ability of the liver X receptor (LXRα [NR1H3] and LXRβ [NR1H2]) agonist, T0901317, to activate the farnesoid X receptor (FXR [NR4H4]). Although T0901317 is a much more potent activator of LXR than FXR, this ligand actually activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid.Thus, the FXR … spark shop gisborne https://helispherehelicopters.com

pGreenFire1-LXRE-in-Cyp7A1 Lentivector System Biosciences

Web1 sept. 2000 · The LXRs mediate oxysterol-regulated transcriptional induction of cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme of the classic bile acid biosynthetic pathway.Lxrα-knockout mice fed a high cholesterol diet fail to up-regulate CYP7A1 expression and bile acid production, thereby accumulating cholesterol ester in their livers . Web“胆固醇增高患者的饮食调理”出自《中国民间疗法》期刊2010年第4期文献，主题关键词涉及有等。钛学术提供该文献下载服务。 WebThis study is the first to show that DXXK could alleviate lipid disorder and ameliorate atherosclerosis with downregulation of the PCSK9 in high-fat diet-fed ApoE–/– mice, suggesting that D XXK may be a potential novel therapeutic treatment and may support statin action in the treatment of atherosclerotic cardiovascular disease. Numerous risk … techies elephant

Nuclear Receptor Regulation Abdominal Key

Category:Cyanidin‐3‐O‐β‐glucoside upregulates ... - Wiley Online Library

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Lxrα-cyp7a1

Transthyretin Regulated by linc00657/miR-205-5p ... - ScienceDirect

Web肝x受体有两个亚型被分辨出来，分别是肝x受体α与肝x受体β，根据核受体命名规则这两个亚型分别被命名为nr1h3（lxrα）与nr1h2（lxrβ）。肝x受体的两个亚型在1994、1995年间先后被分离出来。肝x受体α是由两个研究小组独立发现的，他们分别授予其rld-1 与lxr的名称。 WebLipid efflux mechanisms, relation to disease and potential therapeutic aspects

Lxrα-cyp7a1

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Web10 ian. 2001 · The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol homeostasis. Oxysterol receptor, … Web6 oct. 2009 · The classical pathway begins with the rate-limiting 7-α hydroxylation of cholesterol by cholesterol 7-α hydroxylase (CYP7A1) and the 12-α hydroxylation of the intermediates by sterol 12-α hydroxylase ... The receptor LXRα has never been previously described in the human ovary , ...

Web12 apr. 2012 · In mouse primary hepatocytes, cyanidin-3-O-β-glucoside treatment increased bile acid synthesis and CYP7A1 expression in a liver X receptor alpha (LXRα)-)-dependent manner. Scintillation proximity and time-resolved fluorescence resonance energy transfer assays revealed that cyanidin-3-O-β-glucoside functions as an agonist of LXRα. Conclusion Webる．そこで，LXRαにより同様に調節を受けるsterol regulatory element binding protein (SREBP)-1c，fatty acid synthase (FAS) および胆汁酸生合成の律速酵素で あるcholesterol 7α-hydroxylase (CYP7A1) のmRNA発 現量を測定した．FASmRNAはCAS群に比較し，SPI

WebActivation of LXRα increases the expression of its target genes (ABCA1, ABCG1, CYP7A1) (Lobaccaro et al. Citation 2001; Graham and Allen Citation 2015), but such activation may also lead to physiological effects such as increased TG synthesis in the liver, which may be related to EEG with a greater effect on TG regulation than TC (Zhu and Li ... WebCholesterol mainly reverses transport into the liver by high-density lipoprotein (HDL); then, a third of them are converted into bile acid through the classical pathway (mainly by Cyp7a1 and Cyp8b1) or alternative pathways (mainly by Cyp27a1 and Cyp7b1). 6 Cholesterol transport is mediated by many membrane transporters, including ATP-binding ...

Web在肝脏，fxr上调小异二聚体伴侣（shp）表达，后者抑制胆汁酸合成的限速酶，胆固醇7α-羟化酶（cyp7a1）的表达。 FXR还诱导FGF19表达，从而激活肝FGF受体4（FGFR4）， …

Web26 apr. 2002 · CYP7A1 plays an important role in the regulation of bile acid biosynthesis and cholesterol homeostasis. The oxysterol receptor, LXRα, stimulates whereas the bile acid … techies favorite cell phoneWeb（4）臣药三七主要成分人参皂苷rb1、compound k和臣药女贞子主要成分齐墩果能上调肝细胞lxrα，并上调cyp7a1。 （5）sirna干扰抑制lxrα、hnf4α、pparα蛋白表达后，小檗碱，橙皮苷等对肝细胞cyp7a1上调作用大部分被阻断。说明ftz通过多种成分同时调节hnf4α、pparα、lxrα ... spark shop haweraWeb26 apr. 2002 · Dietary cholesterol stimulates CYP7A1 transcription via activation of oxysterol receptor, LXR alpha, whereas bile acids repress transcription through FXR-mediated … techies incWebConclusion: Our results indicate that the hypocholesterolemic activity of cyanidin-3-O-β-glucoside was, at least in part, mediated by activating the potential LXRα-CYP7A1-bile … techies infotech - digital marketing mohaliWebhon p.1 [100%] 343 名古屋市立大学大学院薬学研究科分子生物薬学分野 （〒467 8603 名古屋市瑞穂区田辺通3 1） e-mail: p052715＠phar.nagoya-cu.ac.jp techies gifWeb1 apr. 2003 · Although it was reported that the expression of human CYP7a1, in contrast to rat CYP7a1, is not stimulated by LXRα [47], CYP7a1 and LXRα expressions in HepG2 … sparkshop nzWeb7 feb. 2015 · lxrα 通过激活 cyp7a1 转录来控制这种级联过 程。通过对lxrα 缺失鼠的分析为这一过程提供了 生理学证据，该种鼠在对胆固醇反应过程中不能上 调cyp7a1 表达，结果肝脏胆固醇快速累积达到毒 性水平。 techieshub