WebJul 7, 2024 · Reanalysis of BIG 1-98, SOFT, and TEXT Trials: Focus on Clinical High-Risk Subgroups. By: Celeste L. Dixon Posted: Thursday, July 7, 2024. Given recent trial results for adjuvant CDK4/6 inhibitors in treating breast cancer, Meredith M. Regan, FASCO, ScD, of Dana-Farber Cancer Institute, Boston, and colleagues decided to reanalyze the results of … WebThe SOFT and TEXT clinical trials produced practice changing results in the treatment of breast cancer in young women, who may have a poorer long-term prognosis. The research …
Adjuvant Exemestane with Ovarian Suppression in …
WebSep 27, 2024 · Several trials evaluated the role of ovarian function suppression for the adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer. Based on the results of the SOFT and TEXT trials, international guidelines recommend the addition of ovarian function suppression to standard adjuvant endocrine … WebAug 20, 2024 · The SOFT-TEXT trial found that OFS+steroidal AI (EXM) had a better 5-year DFS than OFS+TAM. However, there was no statistic difference between the 2 groups in … heron eat fish
Absolute Improvements in Freedom From Distant Recurrence to …
WebSOFT and TEXT are phase III clinical trials developed in parallel to test the optimal post-operative (i.e. adjuvant) endocrine treatment in premenopausal women with hormone … Webthe SOFT and TEXT trials, an ASCO clinical practice guideline on ovarian suppression was published in 2016.6 At that time, the ASCO recommendations were largely congruent with those from the National Com-prehensive Cancer Center Network,7 the St Gallen International Expert Consensus,8 and the SOFT and TEXT investigators.2 For adjuvant therapy ... WebDec 8, 2024 · Meredith M. Regan, ScD, Harvard Medical School, Boston, MA, gives an update on the 12-year follow-up results of the SOFT (NCT00066690) and TEXT (NCT00066703)... heron eating gopher